Keep track of Closely (1)mitotane decreases levels of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is a strong inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for probable dosage adjustments.Headache, intermittent claudication, muscle mass pains, numbnes